CKD and liver inflammation are increasingly understood as axis-level dysfunctions rather than isolated organ failures, often involving immune activation and gut-derived inflammatory signaling.

Hepatic immune overload increases circulating toxins that the kidney must filter, amplifying renal stress. Gut dysbiosis elevates LPS levels, activating TLR4-mediated inflammatory cascades that accelerate organ decline.

 

CIAR’s approach:
   •    Strengthens gut→immune→brain communication across the axis    
   •    Reduces kidney overload
   •    Supports liver detox pathways
   •    Lowers inflammation throughout the axis

This stabilizes organ function and slows disease progression.