
Joint Health – Joint–Gut–Immune–Brain Axis

Chronic joint diseases like Rheumatoid Arthritis (RA) and Osteoarthritis (OA) are characterized by persistent synovial inflammation overtime.
CIAR interprets joint disorders not only as localized pathology but as manifestations of broader immune-metabolic dysregulation.
A disrupted gut environment releases inflammatory signals that activate immune mediators that influence synovial immune activity.
Neuro-immune vagal reflexes that normally regulate inflammation may weaken, allowing synovial inflammation to persist.
CIAR focuses on:
• Calming synovial inflammation
• Restoring gut barrier integrity
• Improving vagus nerve reflex
• Reducing inflammatory drivers associated with joint stiffness and swelling.
This integrated approach supports joint function and long-term inflammatory balance.
_edited.jpg)