The Bio-Intelligence Circuit explains interconnected biological processes commonly observed in chronic inflammatory states:

 

 

 1. Mitochondrial stress → reduced cellular energy & immune instability

   2. Increased gut permeability →  LPS translocation and innate immune activation

  3. TLR4 NF-κB  signaling amplification → Persistent  inflammatory signaling loops

  4. Nuclear receptor imbalance (VDR, GR, ER, TR, PPAR) affecting immune regulation

 5. Suppression of Vagal anti-inflammatory reflex pathways

 6. Cross-axis organ stress and communication dysregulation

 7. Maintenance of Chronic inflammatory states.

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BIC represents the central conceptual framework developed at CIAR to study immune dysregulation, cross-organ stress, and long-standing inflammatory patterns through a systems biology lens.