The Bio-Intelligence Circuit explains the chain reaction that drives chronic inflammation:

   1.    Mitochondrial stress → reduced energy & immune instability
   2.    LPS leakage → innate immune activation
   3.    TLR4 signaling surge → chronic inflammatory loop
   4.    Nuclear receptor imbalance (VDR, GR, ER, TR, PPAR)
   5.    Vagal inflammatory reflex suppression
   6.    Cross-axis organ dysfunction
   7.    Chronic inflammatory state

BIC is the central scientific model used at CIAR to understand immune confusion, organ stress, and long-standing inflammation.